Symptom cluster
Gastrointestinal symptoms
Gut symptoms that are not separate from the rest. The microbiome links to immune, nerve, and brain pathways. This page covers: GI symptoms (diarrhea, nausea, abdominal pain, altered motility, IBS-like).
What causes it
The leading explanations, each with its evidence grade and audit status.
Gut dysbiosis (SCFA-producer depletion, pathobiont enrichment) produces GI symptoms (diarrhea, nausea, abdominal pain, altered motility, IBS-like).
grademoderateauditwell-founded-associationendpointpatient-reported-outcome
sources: S117, S122
Mast cell activation produces GI symptoms (diarrhea, nausea, abdominal pain, altered motility, IBS-like).
gradelow-moderateauditemergingendpointpatient-reported-outcome
sources: S140, S142
Under review
Microbiome signatures track symptom clusters even when viral RNA is undetectable, which is why dysbiosis is treated as a semi-autonomous driver.