TRPM3 channel

https://longcovidatlas.org/glossary/trpm3-channel

In plain language

What it is

A calcium gate on immune cells that appears to work poorly in post-viral illness.

Why it matters

It is studied as a possible mechanism and drug target in ME/CFS and long COVID.

Think of it like

A faulty gate that lets too little calcium into the cell.

For specialists

Formal definition

Transient receptor potential melastatin 3, a calcium-permeable channel; impaired function reported in natural killer cells in ME/CFS.

Mechanism

Disrupted calcium signaling may impair immune-cell function; naltrexone interacts with this pathway.

Sources