Long COVID Atlas
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Plain-language first, with specialist detail below. For understanding, not medical advice.

Long COVID AtlasGlossary › Viral persistence

Mechanism

Viral persistence

https://longcovidatlas.org/glossary/viral-persistence

In plain language

What it is

The idea that pieces of the virus, or the whole virus, linger in the body long after the infection seems over.

Why it matters

A lingering reservoir could keep the immune system and blood vessels switched on for months.

Think of it like

Embers that never fully went out, quietly keeping the fire alarm ringing.

For specialists

Formal definition

Persistence of SARS-CoV-2 RNA, antigen, or replication-competent virus in tissue reservoirs after acute infection.

Mechanism

Persistent antigen sustains immune activation and ongoing endothelial irritation.

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